Title of article
Distribution of 16α-[18F]fluoro-estradiol-3,17β-disulfamate in rats, tumour-bearing mice and piglets
Author/Authors
P. Brust، نويسنده , , H. Rodig، نويسنده , , J. R?mer، نويسنده , , H. Kasch، نويسنده , , R. Bergmann، نويسنده , , F. Füchtner، نويسنده , , D. Zips، نويسنده , , M. Baumann، نويسنده , , J. Steinbach، نويسنده , , B. Johannsen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
9
From page
687
To page
695
Abstract
Based on a high affinity to the enzyme estrone sulfatase (ES), 16α-[18F]fluoroestradiol-3,17β-disulfamate ([18F]FESDS) has been suggested as a potential PET radiotracer for imaging steroid-dependent breast tumours. The distribution of [18F]FESDS was studied in rats, tumour-bearing nude mice and piglets. In all species evidence for binding to a second target, the enzyme carbonic anhydrase (CA), was obtained. ES and CA inhibitors significantly reduced the radiotracer uptake in various organs but not in tumours. It is concluded that [18F]FESDS binds to ES and CA in vivo but this binding is not strong enough to allow tumour imaging with positron emission tomography (PET).
Keywords
carbonic anhydrase , Disulfamate , Estrone sulfatase , positron emission tomography , steroids , 18F , tumour
Journal title
Applied Radiation and Isotopes
Serial Year
2002
Journal title
Applied Radiation and Isotopes
Record number
541354
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