Title of article :
Syntheses, in vitro and in vivo characterization of a 99mTc-(I)-tricarbonyl-benzylamino-dihydroxymethyl phosphine (NP2) chelate
Author/Authors :
K. K. Kothari، نويسنده , , G. K. Raghuraman، نويسنده , , N. K. Pillarsetty، نويسنده , , T. J. Hoffman، نويسنده , , N. K. Owen، نويسنده , , K. V. Katti، نويسنده , , W. A. Volkert، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Studies were performed to study the complexation chemistry of 99mTc(CO)+3 with a new tridentate amino-dihydroxymethyl phosphine (NP2) ligand with the 99mTc(CO)3(OH2)+3 synthon at tracer levels. A single, well-defined 99mTc(CO)3NP2 complex is formed at pH 7.5 within 10 min at 60°C that exhibits high in vitro and in vivo stability.
Keywords :
Technetium-99 , Bifunctional chelating agent , Tc(I) carbonyl , Hydroxymethyl phosphine ligands
Journal title :
Applied Radiation and Isotopes
Journal title :
Applied Radiation and Isotopes
