Title of article
Improved synthesis of anti-[18F]FACBC: improved preparation of labeling precursor and automated radiosynthesis
Author/Authors
Jonathan McConathy، نويسنده , , Ronald J. Voll، نويسنده , , Weiping Yu، نويسنده , , Ronald J. Crowe، نويسنده , , Mark M. Goodman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
10
From page
657
To page
666
Abstract
The non-natural amino acid anti-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid (FACBC) has shown promise for tumor imaging with positron emission tomography. An improved synthesis of the precursor of anti-[18F]FACBC has been devised which demonstrates high stereoselectivity and suitability for large-scale preparations. An automated radiosynthesis has been developed which provides anti-[18F]FACBC in 24% decay-corrected yield. Additionally, the major non-radioactive species present in doses of anti-[18F]FACBC has been identified as anti-1-amino-3-hydroxycyclobutane-1-carboxylic acid. Together, these results are important steps towards the routine production of anti-[18F]FACBC for human use.
Keywords
Fluorine-18 labeled amino acids , Automated synthesis , Tumor imaging
Journal title
Applied Radiation and Isotopes
Serial Year
2003
Journal title
Applied Radiation and Isotopes
Record number
541480
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