Author/Authors :
P. Stoliar، نويسنده , , A. J. Kreiner، نويسنده , , M. E. Debray، نويسنده , , M. E. Caraballo، نويسنده , , A. A. Valda، نويسنده , , J. Davidson، نويسنده , , M. Davidson، نويسنده , , J. M. Kesque، نويسنده , , H. Somacal، نويسنده , , H. DiPaolo، نويسنده , , A. A. Burlon، نويسنده , , M. J. Ozafr?n، نويسنده , , P. Garcia-Navarro and M. E. Vazquez-Cendon، نويسنده , , D. Minsky، نويسنده , , E. M. Heber، نويسنده , , V. A. Trivillin، نويسنده , , A. E. Schwint، نويسنده ,
Abstract :
Microdistributions of the prospective BNCT-compound CuTCPH, a carborane-containing tetraphenylporphyrin with one Cu atom in its molecular structure, have been obtained in tissue sections of different organs of tumor-bearing and normal Syrian hamsters injected with the boron compound by employing a heavy ion microbeam. High resolution X-ray spectroscopy following micro-PIXE (Particle Induced X-ray Emission with micrometer-sized beams) with a focused 16O ion beam was used. Focusing was performed with a heavy-ion scanning high-precision magnetic quadrupole triplet microprobe. Squamous Cell Carcinomas were induced on the right Cheek Pouch of Syrian Hamsters (HCP), sampled, cryo-sectioned and freeze-dried. Two-dimensional maps of elemental concentration were obtained by scanning the beam over the samples. Very non-uniform Cu concentrations were found in all sections.
Keywords :
Hamster cheek pouch model , PIXE X-ray spectroscopy , Microdistributions of BNCT-Compound CuTCPH , Heavy ion microbeam
