Effects of processing conditions and in vitro ageing on the physical properties of Biomer®

Biomer® is generally processed by repeated deposition of layers by solution casting onto a pre-shaped former. The precise nature of this processing route may influence the mechanical response and surface properties of the finished article and, as a result, its subsequent in vivo behaviour. Here we have studied the influence of a range of processing parameters: the type of former, the initial concentration of the solution from which the layers are cast and the time interval between casting of successive layers. The subsequent variation of physico-chemical properties on in vitro ageing in isotonic saline solution has also been considered and, in particular, the possibility of cross-linking during long-term exposure.