Author/Authors :
Elisabetta Cenni، نويسنده , , Gabriela Ciapetti، نويسنده , , Donatella Granchi، نويسنده , , Lucia Savarino، نويسنده , , Alessandra Corradini، نويسنده , , Melania Vancini، نويسنده , , Alessandro Di Leo، نويسنده ,
Abstract :
The expression of thrombomodulin after contact with CMW® 1 bone cement extracts was studied in human umbilical vein endothelial cells. Cement extracts after 1 h and 7-day curing induced no significant variations in thrombomodulin antigen levels and in mRNA expression. Significant increase of thrombomodulin was observed when endothelial cells were treated with all-trans retinoic acid (ATRA). ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW® 1 bone cement does not impair the expression of thrombomodulin in endothelial cells.
