Title of article :
Tissue response to polyanionic collagen: elastin matrices implanted in rat calvaria
Author/Authors :
Fabiana Paim Rosa، نويسنده , , Raphael Carlos Comelli Lia، نويسنده , , Kaline Ol?mpia Fernandes de Souza، نويسنده , , Gilberto Goissis، نويسنده , , Elcio Marcantonio Jr، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
The tissue response to polyanionic collagen matrices, prepared from bovine pericardium and implanted subperiosteally in rat calvaria, was studied. The materials were implanted in 72 male rats (Rattus norvegicus, albinus, Holtzman), randomly divided into four groups: GI-MBP hydrolyzed for 24 h; GII-MBP hydrolyzed for 36 h; GIII-MBP hydrolyzed for 48 h; GIV-native MBP. The materials were explanted after 15, 30 and 60 days and analyzed by routine histological procedures. Except for group IV (native bovine pericardium), polyanionic collagen from groups GI, GII and GIII showed low inflammatory reaction associated with bone formation, partially or completely integrated to the cranial bone; group GIV was characterized by an intense inflammatory reaction with occasional dystrophic mineralization and with occasional bone formation at 60 days when there was a decrease in the inflammatory reaction. Thus, the MBP from groups I, II and III were biologically compatible, enhancing bone formation with a slight delay at 60 days in GII.
Keywords :
Polyanionic collagen , Biocompatibility , Osteogenesis , bone substitute
Journal title :
Biomaterials
Journal title :
Biomaterials