Title of article :
Development of a large titanium bone chamber to study in vivo bone ingrowth
Author/Authors :
Gerjon Hannink، نويسنده , , Per Aspenberg، نويسنده , , Willem Schreurs، نويسنده , , Pieter Buma، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
7
From page :
1810
To page :
1816
Abstract :
In the bone conduction chamber (BCC) various materials and factors have been tested for their effect on bone graft incorporation and bone healing. However, biomaterials often have to be crushed to fit in this small chamber. Since cellular responses to biomaterials are influenced by the size and shape of particles, research concerning the evaluation of biomaterials is limited by the dimensions of this bone chamber. We enlarged and modified the BCC in order to be able to investigate the in vivo influences of biomaterials, growth factors and bone graft processing on tissue and bone ingrowth. Seven goats received four bone chambers each, three modified models and a BCC. The first model (BCC+) had two ingrowth openings, similar to that of the BCC. The second model had two round ingrowth openings (ROU). The third model had a open bottom for bone ingrowth (BOT). After 12 weeks, bone ingrowth distances were measured on histological sections and using μCT. Bone ingrowth was significantly higher (p=0.009 and 0.008) in the ROU compared to the BCC+ and the BOT, respectively. Similar results were found using μCT. The ROU model performed most similar to the BCC (gold standard) and is considered to be a promising new tool in biomaterials research.
Keywords :
Bone remodelling , Histomorphometry , In vivo test , Bone ingrowth , image analysis
Journal title :
Biomaterials
Serial Year :
2006
Journal title :
Biomaterials
Record number :
546821
Link To Document :
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