Author/Authors :
Kanchan Kothari، نويسنده , , Sudhanand Prasad، نويسنده , , Aruna Korde، نويسنده , , Archana Mukherjee، نويسنده , , Archana Mathur، نويسنده , , Manu Jaggi، نويسنده , , Meera Venkatesh، نويسنده , , Ambikalmajan M.R. Pillai، نويسنده , , Rama Mukherjee، نويسنده , , Natesan Ramamoorthy، نويسنده ,
Abstract :
Vasoactive intestinal peptide (VIP) receptors are expressed abundantly on many types of tumors and, hence, radiolabeled VIP analogues are being explored for tumor imaging and therapy. Here, we report synthesis of three VIP analogues and their radiolabeling with 99mTc via a novel tricarbonyl synthon. The radiolabeled product could be prepared in high yields (>95%) and stability. In vitro studies showed significant uptake of 99mTc(CO)3-VP05 in human colon carcinoma cells. Biodistribution studies in animal tumor model showed 0.4–1% ID/g tumor uptake.
