Abstract :
• Platelets, derived from megakaryocte cytoplasm, have a critical role in normal haemostasis, and in thrombotic disorders.
• The development of megakaryocytes is controlled by thrombopoietin, which binds to c-mpl on the surface of platelets and megakaryocytes.
• Platelet membrane glycoproteins mediate binding to subendothelial tissue and aggregation into haemostatic plugs.
• Thrombocytopenia and disorders of platelet function cause petechiae and mucocutaneous bleeding.
• Drugs causing specific inhibition of platelet function are important in the treatment of cardiovascular and cerebrovascular disease.
