Platelets Review Article

• Platelets, derived from megakaryocte cytoplasm, have a critical role in normal haemostasis, and in thrombotic disorders. • The development of megakaryocytes is controlled by thrombopoietin, which binds to c-mpl on the surface of platelets and megakaryocytes. • Platelet membrane glycoproteins mediate binding to subendothelial tissue and aggregation into haemostatic plugs. • Thrombocytopenia and disorders of platelet function cause petechiae and mucocutaneous bleeding. • Drugs causing specific inhibition of platelet function are important in the treatment of cardiovascular and cerebrovascular disease.