Title of article
Pharmacogenetic prediction of clozapine response Original Research Article
Author/Authors
MJ Arranz، نويسنده , , J Munro، نويسنده , , J Birkett، نويسنده , , A Bolonna، نويسنده , , D Mancama، نويسنده , , M Sodhi، نويسنده , , KP Lesch، نويسنده , , JFW Meyer، نويسنده , , P Sham، نويسنده , , DA Collier، نويسنده , , RM Murray، نويسنده , , RW Kerwin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
2
From page
1615
To page
1616
Abstract
We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine in schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76·7% success in the prediction of clozapine response (p = 0·0001) and a sensitivity of 95% (±0·04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.
Journal title
The Lancet
Serial Year
2000
Journal title
The Lancet
Record number
551792
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