Author/Authors :
Natasha Coyle، نويسنده , , Ian Jones، نويسنده , , Emma Robertson، نويسنده , , Corinne Lendon، نويسنده , , Nick Craddock، نويسنده ,
Abstract :
Up to half of parous females with bipolar disorder (manic depression) develop an episode of severe psychiatric disturbance, usually called puerperal psychosis, within a few days of giving birth. We report significant evidence (p<0·003) that variation at the serotonin transporter gene exerts a substantial (odds ratio=4) and important (population attributable fraction=69%) influence on susceptibility to such episodes.