Title of article
Delta 32 deletion of CCR5 gene and association with asthma or atopy
Author/Authors
Tracey J Mitchell، نويسنده , , Andrew J Walley، نويسنده , , James W. Pease، نويسنده , , Patrick J.W Venables، نويسنده , , Steven Wiltshire، نويسنده , , Timothy C. Williams، نويسنده , , William OCM Cookson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
2
From page
1491
To page
1492
Abstract
The CCR5-Δ32 deletion polymorphism (CCR5-Δ32) was investigated for linkage and association to asthma and atopy using two panels of nuclear families containing 1284 individuals. No statistically significant linkage to asthma/ wheeze or atopy was observed in either of the two panels of families. Multiallelic transmission disequilibrium tests (TDT) of the combined data found no significant association for atopy (52 independent alleles transmitted, 51 non-transmitted) or asthma/wheeze (39 transmitted, 44 non-transmitted). Although functional evidence might suggest that CCR5 is a good candidate gene for atopic asthma, this study provides no genetic evidence from CCR5-Δ32 polymorphism to support this hypothesis.
Journal title
The Lancet
Serial Year
2000
Journal title
The Lancet
Record number
553452
Link To Document