Author/Authors :
Reinhard H?pfl، نويسنده , , Kurt Heim، نويسنده , , Neil Christensen، نويسنده , , Klaus Zumbach، نويسنده , , Ulrike Wieland، نويسنده , , Birgit Volgger، نويسنده , , Andreas Widschwendter، نويسنده , , Sandra Haimbuchner، نويسنده , , Elisabeth Müller-Holzner، نويسنده , , Michael Pawlita، نويسنده , , Herbert Pfister، نويسنده , , Peter Fritsch، نويسنده ,
Abstract :
We investigated delayed-type hypersensitivity to human papillomavirus (HPV) in women with cervical dysplasia or cancer. Women were challenged by skin tests with synthetic HPV-16 E7 oncoprotein peptides. 11 women were regressors (cleared disease without treatment) and 37 were progressors (required surgery). Antibodies to early antigens (markers for progression) were detectable in a higher proportion of cancer patients than all other patients, particularly progressors with cervical intraepithelial neoplasia (CIN). By contrast, cellular immunity to HPV-16 E7, measured by skin test, was significantly (p=0·0001) associated with clinical and cytological resolution of HPV-induced CIN, indicating that E7-specific T-helper cells have a role in control of HPV.
