Title of article
Methadone, ciprofloxacin, and adverse drug reactions
Author/Authors
Karin Herrlin، نويسنده , , M?rta Segerdahl، نويسنده , , Lars E. Gustafsson، نويسنده , , Eija Kalso، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
2
From page
2069
To page
2070
Abstract
Ciprofloxacin, given to a patient successfully treated with methadone for more than 6 years, caused profound sedation, confusion, and respiratory depression. We suggest that this was caused by ciprofloxacin inhibition of CYP1A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the metabolism of methadone.
Journal title
The Lancet
Serial Year
2000
Journal title
The Lancet
Record number
553915
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