Title of article :
Vanilloid receptor 1 immunoreactivity in inflamed human bowel
Author/Authors :
C. Yiangou، نويسنده , , Keri Facer، نويسنده , , NHC Dyer، نويسنده , , CLH Chan، نويسنده , , C Knowles، نويسنده , , NS Williams، نويسنده , , P Anand، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
2
From page :
1338
To page :
1339
Abstract :
Vanilloid receptor 1 (VR1) is expressed by sensory neurons. Once activated, these neurons evoke the sensation of burning pain and release neuropeptides that induce neurogenic inflammation. We used immunoblotting and immunostaining to estimate the density of VR1 in colonic tissues of patients with inflammatory bowel disease and of controls. Our study results indicate that VR1 immunoreactivity is greatly increased in colonic nerve fibres of patients with active inflammatory bowel disease. Thus, the discovery of new drugs that can bind the VR1 receptor, or antagonise endogenous inflammatory substances that activate this receptor, could lead to new therapies for pain and dysmotility.
Journal title :
The Lancet
Serial Year :
2001
Journal title :
The Lancet
Record number :
555108
Link To Document :
بازگشت