Title of article
Reflux of gastric juice and glue ear in children
Author/Authors
Andrea Tasker، نويسنده , , Peter W. Dettmar، نويسنده , , Marguerite Panetti، نويسنده , , James A Koufman، نويسنده , , John P Birchall، نويسنده , , Jeffery P Pearson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
1
From page
493
To page
493
Abstract
Otitis media with effusion (glue ear) is the most frequent cause of deafness in children. We investigated the role of gastric juice reflux in this disease. We measured pepsin concentrations in middle ear effusions from children using ELISA and enzyme activity assays. 45 (83%) of 54 effusions contained pepsin/pepsinogen at concentrations of up to 1000-fold greater than those in serum. Our data suggest that reflux of gastric juice could be a major cause of glue ear in children.
Journal title
The Lancet
Serial Year
2002
Journal title
The Lancet
Record number
555633
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