Author/Authors :
Jason D Maguire، نويسنده , , Iwa W Sumawinata، نويسنده , , Sofyan Masbar، نويسنده , , Budhi Laksana، نويسنده , , Purnomo Prodjodipuro، نويسنده , , Ika Susanti، نويسنده , , Priyanto Sismadi، نويسنده , , Nurlis Mahmud، نويسنده , , Michael J Bangs، نويسنده , , J Kevin Baird، نويسنده ,
Abstract :
Oral chloroquine is the treatment of choice for uncomplicated Plasmodium malariae infections worldwide. We did a prospective 28-day in-vivo assessment of the efficacy of chloroquine for treatment of P malariae on Legundi Island in Lampung Bay, Sumatra, Indonesia. Of 28 patients, one had recurrent parasitaemia on day 28, and two had persistent parasitaemia to day 8. Whole-blood chloroquine and desethylchloroquine concentrations were at ordinarily effective levels ( 100 μg/L) on day 8 in both cases of persistent parasitaemia. These findings suggest that clinical resistance to chloroquine by P malariae occurs in the Indonesian archipelago of southeast Asia.
