Title of article :
Methylation changes in faecal DNA: a marker for colorectal cancer screening?
Author/Authors :
Hannes M Müller، نويسنده , , Michael Oberwalder، نويسنده , , Heidi Fiegl، نويسنده , , Maria Morandell، نويسنده , , Georg Goebel، نويسنده , , Matthias Zitt، نويسنده , , Markus Mühlthaler، نويسنده , , Dietmar ?fner، نويسنده , , Raimund Margreiter، نويسنده , , Martin Widschwendter، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
3
From page :
1283
To page :
1285
Abstract :
DNA methylation is a common molecular alteration in colorectal cancer cells. We report an assessment of faecal DNA from patients with colorectal cancer and controls to determine the feasibility, sensitivity, and specificity of this approach. By use of MethyLight analysis of faecal DNA from three independent sets of patients, we identified SFRP2 methylation as a sensitive single DNA-based marker for identification of colorectal cancer in stool samples (sensitivity 90% [CI 56–100] and specificity 77% [46–95] in the training set [n=23]; sensitivity 77% [46–95] and specificity 77% [46–95] in an independent test set [n=26]). Whether a combination of genetic and epigenetic markers will identify colorectal cancer at an early stage remains to be shown.
Journal title :
The Lancet
Serial Year :
2004
Journal title :
The Lancet
Record number :
560702
Link To Document :
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