Title of article
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
Author/Authors
Katarina Le Blanc، نويسنده , , Ida Rasmusson، نويسنده , , Berit Sundberg، نويسنده , , Cecilia G?therstr?m، نويسنده , , Moustapha Hassan، نويسنده , , Mehmet Uzunel، نويسنده , , Olle Ringdén، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
1439
To page
1441
Abstract
Summary
Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo
Journal title
The Lancet
Serial Year
2004
Journal title
The Lancet
Record number
560768
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