Author/Authors :
S. M. Berry، نويسنده , , R. S. Smith and F. Y. Hadaegh، نويسنده , , M. P. Dombrowski، نويسنده , , K. S. Puder، نويسنده , , D. B. Cotton، نويسنده , , M. P. Johnson، نويسنده , , K. Kithier، نويسنده , , B. Lecolier، نويسنده , , G. Bercau، نويسنده , , L. Bidat، نويسنده ,
Abstract :
When fetal urinary-tract malformations (UTM) are discovered, management is based on the prediction of postnatal renal function, currently made by fetal urinary biochemistry and sonography. Serum β2-microglobulin has been used postnatally to estimate renal function and does not cross the placenta. We investigated the relation between fetal serum β2-microglobulin and renal function by comparing 64 unaffected fetuses and 15 fetuses with UTM. A β2-microglobulin above a 5·6 mg/L cut-off gave cross-validated sensitivity of 80·0%, specificity of 98·6%, a positive predictive value of 88·9%, and a negative predictive value of 97·1% for our cohort study.
