Author/Authors :
Xavier Castellsagué، نويسنده , , Clara Menendez، نويسنده , , Maria-Paz Loscertales، نويسنده , , Janet R Kornegay، نويسنده , , Francisco dos Santos، نويسنده , , F Xavier G?mez-Olivé، نويسنده , , Belen Lloveras، نويسنده , , Nayana Abarca، نويسنده , , Neide Vaz، نويسنده , , Avertino Barreto، نويسنده , , F Xavier Bosch، نويسنده , , Pedro Alonso، نويسنده ,
Abstract :
We studied the genotype distribution of cervical human papillomavirus (HPV) infections in an age-stratified sample of 262 women in Mozambique using the PGMY09-PGMY11 primer system in a reverse line-blot strip-based assay with high sensitivity in type-specific amplification. Despite the low precision of the estimates, we found that HPV-16 was not the dominant type. Instead, HPV 35 was the most commonly identified genotype among HPV-positive women (16/96 [17%]) and women with cervical neoplasia (7/23 [30%]). Certain genotypes might have been under-detected in previous studies, and type-specific HPV distributions might vary across populations. Therefore, the estimated proportion of cervical neoplasia that could be prevented by an HPV-16-based vaccine could be lower than expected.
