Title of article :
Endothelin-1 plays a major role in portal hypertension of biliary cirrhotic rats through endothelin receptor subtype B together with subtype A in vivo
Author/Authors :
Hideyuki Kojima، نويسنده , , Shinya Sakurai، نويسنده , , Shigeki Kuriyama، نويسنده , , Hitoshi Yoshiji، نويسنده , , Hiroo Imazu، نويسنده , , Masahito Uemura، نويسنده , , Yoshihiro Nakatani، نويسنده , , Jyunichi Yamao، نويسنده , , Hiroshi Fukui، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
7
From page :
805
To page :
811
Abstract :
Background/Aims: Endothelin-1 has been suggested to play a key role in cirrhotic portal hypertension, but a role of its receptors in vivo is not fully elucidated. Methods: Biliary cirrhosis was induced by bile duct ligation. Expressions of endothelin-1 and its receptors were evaluated by radioimmunoassay and/or reverse-transcription polymerase chain reaction. Hemodynamics were studied using endothelin receptor agonist or antagonist. Results: Portal pressure and hepatic endothelin-1 concentrations progressively increased in parallel after bile duct ligation. Gene expression of hepatic prepro-endothelin-1 and endothelin B receptor enhanced after bile duct ligation, while that of endothelin A receptor was unchanged. Intraportal administration of endothelin-1 or endothelin B receptor agonist sarafotoxin 6c (0.5 nmol/kg, respectively) progressively raised portal pressure in both sham and cirrhotic rats. Portal hypertensive effect of sarafotoxin 6c was more intense in cirrhotic rats than sham animals. Neither endothelin A receptor antagonist FR139317 (1 mg/kg) nor endothelin B receptor antagonist BQ788 (1 mg/kg) alone ameliorated cirrhotic portal hypertension. Only the combined endothelin A and B blockade was associated with a decrease in portal pressure in cirrhotic rats. Conclusions: These results indicate that endothelin-1 plays a major role in cirrhotic portal hypertension through endothelin receptor subtype B together with subtype A in vivo.
Keywords :
Endothelin receptor , endothelin , portal hypertension , Liver cirrhosis , Bile duct ligation , RNA expression , Hemodynamic study
Journal title :
Journal of Hepatology
Serial Year :
2001
Journal title :
Journal of Hepatology
Record number :
585258
Link To Document :
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