Coronary artery stenting in the aged

OBJECTIVES The study compared the safety and efficacy of coronary artery stenting in aged and nonaged patients and identified predictors of adverse clinical outcomes. BACKGROUND Limited data are available on the outcomes of stenting in the aged (≥80 years) compared to nonaged patients. METHODS The study was a pooled analysis of 6,186 patients who underwent coronary artery stenting in six recent multicenter trials. A clinical events committee adjudicated clinical end points, and quantitative angiography was performed by an independent core laboratory. RESULTS There were 301 (4.9%) aged patients (≥80 years). Compared to nonaged patients, aged patients had a higher prevalence of multivessel disease (16.5% vs. 9.6%, P = 0.001), unstable angina (50.8% vs. 42.1%, P = 0.003), moderate to severe target lesion calcification (30.4% vs. 15.3%, P = 0.001) and smaller reference vessel diameter (2.90 mm vs. 2.98 mm, P = 0.004). Procedural success rate (97.4% vs. 98.5%, P = 0.14) was similar in the two groups. In-hospital mortality (1.33% vs. 0.10%, P = 0.001), bleeding complications (4.98% vs. 1.00%, p < 0.001) and one-year mortality (5.65% vs. 1.41%, p < 0.001) were significantly higher for the aged patients. Clinical restenosis was similar for the two groups (11.19% vs. 11.93%, P = 0.78). Advanced age, diabetes, prior myocardial infarction and presence of three-vessel disease were independent predictors of long-term mortality. CONCLUSIONS Coronary artery stenting can be performed safely in patients ≥80 years of age, with excellent acute results and a low rate of clinical restenosis, albeit with higher incidences of in-hospital and long-term mortality, and vascular and bleeding complications compared to nonaged patients.