Author/Authors :
Soren Schenk، نويسنده , , Stephan Weber، نويسنده , , Dipl Ing، نويسنده , , Viviane Luangphakdy، نويسنده , , Ryan S. Klatte، نويسنده , , Christine R. Flick، نويسنده , , Ji-Feng Chen، نويسنده , , Michael W. Kopcak Jr، نويسنده , , Yoshio Ootaki، نويسنده , , Keiji Kamohara، نويسنده , , Gordon B. Hirschman، نويسنده , , Nicholas G. Vitale، نويسنده , , Peter A. Chapman Jr، نويسنده , , William A. Smith، Jr. نويسنده , , Kiyotaka Fuk، نويسنده ,
Abstract :
Purpose
Downsizing pulsatile devices requires an increase of beat rate if flow capacity is to be maintained. We applied this concept to the preclinical MagScrew total artificial heart (TAH).
Description
The device fills passively with a stroke volume of 45 ml and beat rates up to 250 beats per minute (bpm).
Evaluation
Stable hemodynamics were observed during a 30-day bovine implant with a flow of 8.7 ± 1.2 L/min at beat rates of 204 ± 18 bpm. Device filling was exceptional up to 250 bpm generating flow of greater than 12 L/min. Beat rate adapted to preload in a way similar to a Frank-Starling response. Left and right atrial pressures were balanced. The aortic pulse pressure was 49–70 mm Hg, which translates to a pulsatility index of 0.49–0.77. Organ functions were preserved and blood damage did not occur.
Conclusions
Increasing the beat rate while downsizing the MagScrew TAH was successful with strong flow generation by passive filling. Pulsatility was maintained at high beat rates. This innovative approach may be used to develop small pulsatile pumps.
