Cardiopulmonary bypass, rewarming, and central nervous system dysfunction

Background. During cardiopulmonary bypass anasopharyngeal temperature greater than 38°C at the end of rewarming may indicate cerebral hyperthermia. This could exacerbate an ischemic brain injury incurred during cardiopulmonary bypass. Methods. In a cohort of 150 aortocoronay bypass patients neuropsychologic test scores of 66 patients whose rewarming temperature exceeded 38°C were compared with those who did not. There were no differences between groups with respect to demographic and intraoperative variables. Results. A trend was seen for hyperthermic patients to do worse on all neuropsychologic tests in the early postoperative period but not at 3-month follow-up. By analysis of covariance hyperthermic patients did worse on the visual reproduction subtest of the Weschler memory scale at 3 months (p = 0.02), but this difference was not found by linear regression (p = 0.10). Conclusions. We were unable to demonstrate any significant deterioration in patients rewarmed to greater than 38°C in the early postoperative period. The poorer performance in the visual reproduction subtest of the Wechsler memory scale at 3 months in the group rewarmed to more than 38°C is interesting but far from conclusive. Caution with rewarming is still advised pending more in-depth study of this issue.