Heart transplantation for chronic chagasʹ heart disease

Background Chagasʹ disease has been considered a contraindication to heart transplantation as Trypanosoma cruzi infection could recur after immunosuppression. Methods We report the follow-up of 22 patients who underwent orthotopic heart transplantation for treatment of end-stage chronic Chagasʹ heart disease, divided in two groups. Group 1 consisted of 9 patients operated on from September 1985 to June 1991, and group 2 patients underwent transplantation from July 1991 to June 1995. After our early experience with group 1, we attempted to use a lower cyclosporine dosage in group 2. Results Total actuarial survival at 24 months was 60%, and it was better for group 2 (33% for group 1, 80% for group 2, p = 0.008). Parasitemia occurred similarly in both groups, but Chagasʹ disease reactivation was seen in 5 group 1 patients and in 1 group 2 member (p < 0.002). Neoplasia developed in 5 group 1 patients and 1 group 2 patient, and contributed to death in 3 of them. Conclusions These data demonstrate satisfactory outcome of cardiac transplantation in patients with endstage Chagasʹ heart disease in the second phase of our experience. Further progress is necessary to improve the results and evaluate its proper role in the management of this disease.