A review of liver masses in pregnancy and a proposed algorithm for their diagnosis and management

Background Liver masses in pregnancy are rare; some behave aggressively while others remain indolent. The paucity of case series has hindered the development of a defined approach to their diagnosis and management. This paper presents an algorithm for the diagnosis and management of hepatic hemangiomas, focal nodular hyperplasia, liver cell adenomas and hepatocellular carcinoma associated with pregnancy based on our own experience and literature review. Data sources A Medline search from 1966 to present was performed. Seven additional illustrative cases from our institution are included. Twenty pregnancies with hepatic hemangiomas, 37 with focal nodular hyperplasias, 26 with liver cell adenomas and 33 with hepatocellular carcinomas were identified. Conclusions Gestational hepatic hemangiomas and focal nodular hyperplasia behave indolently and can be observed. Liver cell adenomas often require surgery, but small, asymptomatic lesions may be carefully observed. Meticulous observation postpartum is mandatory. As pregnancy impacts survival in hepatocellular carcinoma, resection maybe indicated.