Title of article :
Adverse effect of splenectomy on recurrence in total gastrectomy cancer patients with perioperative transfusion
Author/Authors :
Jian Guo Shen، نويسنده , , Jae Ho Cheong، نويسنده , , Woo Jin Hyung، نويسنده , , Junuk Kim، نويسنده , , Seung Ho Choi، نويسنده , , Sung Hoon Noh، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
5
From page :
301
To page :
305
Abstract :
Background To investigate the interactions between splenectomy and perioperative transfusion in gastric cancer patients. Methods Medical records of 449 gastric cancer patients who had undergone total gastrectomies for curative intent between 1991 and 1995 were reviewed. The influence of splenectomy on tumor recurrence and survival both in the transfused and nontransfused patients were evaluated by univariate and multivariate analysis. Results The recurrence rate in the splenectomy group was 48.1% as compared with 22.6% in the spleen-preserved group among transfused patients (P = .001); it was 40.7% compared with 26.5% among nontransfused patients (P = .086). There was no significant difference in the mean survival between the splenectomy group and the spleen-preserved group in a subgroup analysis by stage. Multivariate analysis identified splenectomy as an independent risk factor for recurrence but not as a predictor for survival among transfused patients. Conclusions Splenectomy does not appear to abrogate the adverse effect of perioperative transfusion on prognosis in gastric cancer patients. Moreover, it may increase postoperative recurrence in transfused patients.
Keywords :
Transfusion , Splenectomy , Gastric cancer , prognosis
Journal title :
The American Journal of Surgery
Serial Year :
2006
Journal title :
The American Journal of Surgery
Record number :
618380
Link To Document :
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