Is splenectomy more dangerous for massive spleens?

background Reports vary about whether risks are greater for removal of massive (≥1500 g) spleens than for smaller (<1500 g) spleens. We sought to determine the hazards of splenectomy. methods: We reviewed 223 consecutive adults with elective splenectomies for hematologic diseases. Morbidity and mortality rates were combined with published data to create a meta-analysis. results Patients with massive spleens are more likely to have postoperative complications (relative risk [RR] 2.1, 95% confidence interval [Cl] 1.3 to 3.4; P = 0.003) and death (RR 4.7, 95% Cl, 1.5 to 15.1; P = 0.01). However, when the investigation is restricted to comparable diagnoses, patients with massive spleens do not differ from those with smaller spleens regarding complications (RR 1.4, 95% Cl, 0.8 to 2.7; P = 0.3) or mortality (RR 2.1, 95% Cl, 0.5 to 9.7; P = 0.4). These observations are confirmed by metaanalysis. Furthermore, multivariate analysis indicts age as a critical risk of complications and death. conclusions Increased age and underlying illness are the predominant factors associated with morbidity and mortality following splenectomy for hematologic disease. Adjusting for age and diagnosis, spleen size is not a hazard.