Comparion of the Effect of Latanoprot 0.005% and Timolol 0.5% on the Calculated Ocular Perfuion Preure in Patient With Normal-tenion Glaucoma Original Reearch Article

Purpoe: To compare the calculated mean ocular perfuion preure at the end of 3 week’ treatment with latanoprot 0.005% once daily or timolol 0.5% twice daily in normal-tenion glaucoma patient. Method: In a three-center, double-maked, randomized, croover tudy, 36 patient were allocated to two treatment group; one received 3 week each of placebo, latanoprot, placebo, and timolol, wherea the other group had placebo, timolol, placebo, and latanoprot. Intraocular preure and reting ytemic blood preure were meaured at 9 image, 12 noon, and 4 image. Ocular perfuion preure wa calculated for each time period a well a the mean of three value (daytime average). ytemic blood preure and heart rate were alo recorded at 30-minute interval during the lat 24 hour of each treatment period. Reult: The average daytime mean ocular perfuion preure (mean ± EM) following latanoprot treatment wa 53.2 ± 1.4 mm Hg, an increae of 8% from the latanoprot run-in period, compared with 50.9 ± 1.1 mm Hg following timolol treatment, an increae of 2% from the timolol run-in period (P < .05, ANOVA). Timolol reduced the blood preure. The difference in mean daytime and nighttime ytolic blood preure meaurement a well a nighttime diatolic blood preure wa about 5 mm Hg between the latanoprot and timolol treatment. The daytime and nighttime heart rate were alo lower during the timolol treatment. Concluion: Becaue ocular perfuion preure may be important in ome glaucomatou patient, latanoprot appear to affect ocular perfuion preure more favorably than timolol doe in patient with normal-tenion glaucoma.