Proton beam irradiation of choroidal hemangioma Original Reearch Article

PURPOE: To preent a large erie of choroidal hemangioma treated with proton beam irradiation and to decribe the treatment outcome. METHOD: We treated 54 eye of 53 patient with choroidal hemangioma. The leion conited of 48 circumcribed hemangioma and ix diffue hemangioma in patient with turge-Weber yndrome. The total applied doe wa 27.3 Gy in four eye, 22.7 Gy in three eye, and 16.4 Gy to 18.2 Gy in 47 eye. REULT: The retina reattached within ix month after treatment in all 54 eye and no recurrence of the econdary retinal detachment occurred within the follow-up period of 6 month to 9 year. Tumor treated with the higher doe regreed fater than tumor treated with the lower doe, but radiation-induced complication of the optic nerve appeared in all four eye treated with a total doe of 27.3 Gy. Of 31 eye treated with 16.4 to 18.2 Gy and followed for more than 1 year, 22 had an improvement in their viual acuity, and nine retained the ame viual acuity. At the lat follow-up examination, the bet-corrected viual acuity wa 20/20 or better in nine eye, 20/40 to 20/25 in 13 eye, 20/100 to 20/50 in ix eye, and 20/200 or le in three eye. CONCLUION: Proton beam irradiation of choroidal hemangioma appear to be a valid therapeutic alternative. A total proton doe ranging from 16.4 to 18.2 Gy applied in four daily fraction eem adequate to enure local control of both tumor and econdary retinal detachment.