Combined effect of dorzolamide and latanoprot on the rate of aqueou humor flow Original Reearch Article

PURPOE: To determine whether latanoprot, an ocular hypotenive agent believed to enhance uveocleral outflow of aqueou humor, augment the aqueou-uppreing effect of dorzolamide, a topical carbonic anhydrae inhibitor. METHOD: Twenty-four normal ubject underwent meaurement of aqueou humor flow by fluorophotometry to determine the flow with placebo, with dorzolamide, and with a combination of dorzolamide and latanoprot. REULT: The flow of aqueou humor wa uppreed 13% by dorzolamide but not by latanoprot. Latanoprot did not augment the effect of dorzolamide on aqueou humor flow; latanoprot and dorzolamide had additive ocular hypotenive effect. CONCLUION: The uveocleral flow effect of latanoprot doe not improve the aqueou-uppreing effect of dorzolamide, but the two drug have additive ocular hypotenive effect.