Retinal blood flow meaurement in branch retinal vein occluion uing canning laer doppler flowmetry Original Reearch Article

PURPOE: To determine capillary blood flow meaurement in eye with branch retinal vein occluion uing a canning laer Doppler flowmeter. METHOD: Retinal capillary blood flow in branch retinal vein occluion area and correponding ipilateral nonbranch retinal vein occluion area, 11 equivalent area of the contralateral fellow eye of 12 conecutive untreated branch retinal vein occluion patient, and 16 eye of 11 age-matched normal control ubject were meaured with canning laer Doppler flowmetry. A template coniting of eight quare, each with a field of 100 × 100 μm (10 × 10 pixel) with pace interval of 500 μm equiditant horizontally and vertically wa ued to obtain blood flow meaurement in all ubject. Mean blood volume, flow, and velocity were obtained by averaging the mean value meaured in each field. We avoided meaurement over large retinal veel to prevent the aliaing artifact of blood cell from moving fater than the ampling frequency. REULT: Branch retinal vein occluion area have ignificantly decreaed microvacular blood volume (P = .0009), flow (P = .02), and velocity (P = .016) compared with ipilateral nonbranch retinal vein occluion area in the ame eye. Branch retinal vein occluion area alo have decreaed blood volume (P = .001), flow (P = .0042), and velocity (P = .0044) compared with area of contralateral fellow eye of branch retinal vein occluion ubject. Branch retinal vein occluion area have ignificantly decreaed blood volume (P = .0012), flow (P = .008), and velocity (P = .02) compared with age-matched normal area. CONCLUION: Average retinal blood volume, flow, and velocity in area of branch retinal vein occluion are ignificantly lower than in healthy retina. The ability to noninvaively meaure hemodynamic change in the retinal capillary bed may be relevant to development of new therapie for retinovacular dieae.