Human leukocyte antigen aociated with hyperthyroid grave ophthalmopathy in japanee patient Original Reearch Article

PURPOE: To evaluate the aociation of human leukocyte antigen (HLA) type in Japanee patient with Grave ophthalmopathy. METHOD: Japanee patient with evere ophthalmopathy (48 patient) and patient without ophthalmopathy (46 patient) were elected propectively from 234 conecutive patient with hyperthyroid Grave dieae. The criteria for evere ophthalmopathy were proptoi of 19 mm or more, or a 3-mm difference in exophthalmometry meaurement between the two eye, or diplopia at the primary eye poition. The criteria for the abence of ophthalmopathy were proptoi of 16 mm or le, no diplopia, no lid retraction, and no thickening of extraocular mucle. erologic HLA typing of cla I and II antigen wa performed in the two patient group. The frequency of each HLA antigen in the two patient group wa compared to that in 767 unrelated normal healthy Japanee control. REULT: The frequencie of HLA-DR14 and DQ1 were ignificantly higher in the patient group with evere ophthalmopathy (35% and 75%, repectively) than in healthy control (4% and 43%, repectively; corrected P < .05), and alo greater than in the patient group without ophthalmopathy (13% and 55%, repectively; P < .01). On the other hand, the frequencie of HLA-B35, B54, DR4, and DQ4 were ignificantly higher in the patient group without ophthalmopathy (23%, 23%, 43%, and 30%, repectively) than in the patient group with evere ophthalmopathy (13%, 15%, 25%, and 19%, repectively; P < .01). CONCLUION: HLA-DR14 and DQ1 antigen may be genetic marker of predipoition to the development of evere ophthalmopathy. In addition, HLA-B35, B54, DR4, and DQ4 may be genetic marker of reitance to evere ophthalmopathy. Variation in the everity of ophthalmopathy aociated with Grave dieae may depend, in part, on the preence or abence of particular HLA antigen.