Diabete, cardiovacular dieae, elected cardiovacular dieae rik factor, and the 5-year incidence of age-related cataract and progreion of len opacitie: the beaver dam eye tudy Original Reearch Article

PURPOE: To decribe the relationhip of diabete mellitu, cardiovacular dieae, and elected cardiovacular dieae rik factor to cumulative incidence of age-related cataract and to progreion of len opacitie over a 5-year interval. METHOD: A follow-up examination of the Beaver Dam Eye tudy cohort wa performed 5 year after the baeline evaluation. Age at the cenu prior to baeline ranged from 43 to 84 year of age. Protocol for examination, len photography, and grading were the ame for both examination. REULT: Age at baeline wa the mot ignificant characteritic aociated with incidence of nuclear, cortical, and poterior ubcapular cataract in thoe without diabete (P < .001) for all cataract. The poitive aociation of age with cataract wa found for nuclear and cortical cataract in the wore eye (P ≤ .04) but not poterior ubcapular cataract in thoe with diabete. Progreion of nuclear cleroi wa common, occurring in about 70% of ubject when conidering either eye. Incident cortical and poterior ubcapular cataract (P ≤ .001 for wore eye for each leion) and progreion of cortical and poterior ubcapular opacitie were more common in thoe with diabete (P ≤ .001 for either eye for each leion). Increaed glycated hemoglobin level wa aociated with increaed rik of nuclear and cortical cataract in thoe with diabete. Relationhip of rik factor to poterior ubcapular cataract, epecially among thoe with diabete, were often in the expected direction but lacked ignificance poibly due to mall ample. CONCLUION: Diabete mellitu i aociated with incidence over 5 year of cortical and poterior ubcapular cataract and with progreion of more minor cortical and poterior ubcapular len opacitie. Thee change may be related to level of glycemia. Cardiovacular dieae and it rik factor have little effect on incidence of any age-related cataract.