Tranlocation of chromoome 11 and 22 in choroidal metatatic ewing arcoma detected by fluorecent in itu hybridization

PURPOE: To decribe a patient with metatai of Ewing arcoma to the choroid and the molecular genetic of the tumor. METHOD: A 26-year-old woman with metatatic Ewing arcoma developed large choroidal mae in the left eye and died 2 month later. Autopy of the eye wa performed. Dual-color fluorecent in itu hybridization wa ued to detect genetic alteration in the ocular tumor with EW and FLI-1 probe. REULT: Hitopathology confirmed choroidal metatatic Ewing arcoma. Molecular analyi howed chromoomal tranlocation t(11;22)(q24;q12) or EW/FLI-1 rearrangement in the malignant cell of the eye. CONCLUION: Ewing arcoma can rarely metataize to the uvea. Molecular detection of the t(11;22)(q24;q12) tranlocation in Ewing arcoma i valuable in the differential diagnoi of mall round cell tumor.