Dik hemorrhage i a ignificantly negative prognotic factor in normal-tenion glaucoma

PURPOE: We invetigated the relationhip between dik hemorrhage in normal-tenion glaucoma and the progreion of viual field defect and, additionally, whether hemorrhage play a role in the pathogenic proce of the chronic dieae. METHOD: We retropectively reviewed the chart of 70 patient with normal-tenion glaucoma (mean follow-up, 5.6 year) who were not medicated for glaucoma, and we applied a regreion analyi of urvival data baed on the Cox proportional hazard model. everal clinical factor were invetigated to find a poible aociation with the progreion of glaucomatou viual field defined by two different definition: one by mean deviation change and the other by glaucoma change probability analyi. REULT: Dik hemorrhage, corrected-pattern tandard deviation, age, ytolic blood preure, and pule rate had a ignificant influence on the viual field defect. The cumulative probability of progreion of viual field lo wa ignificantly greater for patient with dik hemorrhage than for patient without dik hemorrhage by either criterion for progreion (P ≤ .0008, logrank tet). All eye that had at leat two occurrence of dik hemorrhage howed progreion, wherea only three of nine eye howed progreion in the nonrecurrent dik hemorrhage group by the glaucoma change probability analyi. The difference wa tatitically ignificant (P < .0001, Fiher’ exact probability tet). Furthermore, there wa a ignificant relationhip between the location of the dik hemorrhage and the area of the progreion of viual field lo in 65.4% of progreive patient with dik hemorrhage. CONCLUION: everal clinical factor other than intraocular preure are ignificantly aociated with the progreion of viual field lo during the natural coure of normal-tenion glaucoma. Among thee, dik hemorrhage i a ignificantly negative prognotic factor in patient with normal-tenion glaucoma and may be a ign of progreive damage of the retinal nerve fiber layer, leading to functional deterioration of the viual field.