Predictive value of a 1-day, 1-eye trial on the 1-month ocular hypotenive repone of latanoprot 0.005%

PURPOE: To determine if a 1-day, 1-eye trial of latanoprot 0.005% wa predictive of the 1-month intraocular preure repone in patient with uncontrolled open-angle glaucoma on maximally tolerated medical therapy without latanoprot. METHOD: One eye of 39 conecutive patient wa enrolled in propective trial of latanoprot 0.005%. An invetigator maked to treatment eye and intraocular preure reult meaured intraocular preure at 1 day and 1 month after treatment. The diagnotic preciion of the 1-day, 1-eye trial for the 1-month reult wa determined at a 10%, 20%, and 30% reduction from baeline intraocular preure. REULT: Treatment produced a mean ± D (range) decreae in intraocular preure from 20.9 ± 4.6 (14 to 35) mm Hg to 16.6 ± 3.6 (9 to 26) mm Hg at 24 hour (P < .0001, paired t tet). Thi reduction in intraocular preure wa imilar at 1 month with mean ± D (range) intraocular preure of 16.1 ± 3.1 (9 to 22) mm Hg (P < .0001, paired t tet). The accuracy of the 1-day, 1-eye trial for the 1-month repone at a 10%, 20%, and 30% reduction of intraocular preure from baeline intraocular preure wa 96% (chi QUARE = 29.5, P < .001), 74% (chi QUARE = 8.4, P = .004), and 80% (chi QUARE = 10.2, P = .001), repectively. CONCLUION: A 1-day, 1-eye trial of latanoprot 0.005% i predictive of the 1-month intraocular preure repone in patient with uncontrolled open-angle glaucoma.