Pulatile ocular blood flow in primary open-angle glaucoma and ocular hypertenion

Purpoe To compare pulatile ocular blood flow meaurement in untreated ocular hypertenive (OHT) ubject and primary open-angle glaucoma (POAG) patient. Deign A propective obervational tudy in an intitutional etting. Method A total of 97 ubject were recruited to the tudy (50 ocular hypertenive, 24 glaucoma patient, and 23 normal ubject). “High-rik” OHT had intraocular preure (IOP) > 25 mm Hg; “low-rik” OHT had IOP ≤ 25 mm Hg. Pulatile ocular blood flow (POBF) meaurement were made with a pneumotonometer in itting, tanding, and upine poition. Intraocular preure wa meaured with Goldmann tonometry. Twenty-ix patient were tarted on topical treatment to reduce intraocular preure, and the meaurement were repeated at a review viit. Reult Untreated POAG patient and high-rik OHT had reduced POBF (P < .001) and pule volume (P < .001) compared with both normal and low-rik OHT. Women had higher POBF than men (P = .009, two-way analyi of variance). ubject with pharmacologically lowered IOP had a ignificant increae in mean POBF (+80.9 μl/min, P = .02) and a ignificant reduction in mean arterial blood preure (−11.0 mm Hg, P = .003). Potural reduction in POBF (from itting to upine) increaed and became tatitically ignificant in POAG and OHT ubject on treatment (P < .0001). Concluion High-rik ocular hypertenive have reduced POBF when compared with low-rik ocular hypertenive and normal and do not differ ignificantly from POAG patient. Our finding upport the clinical impreion that ocular hypertenive ubject with IOP of over 25 mm Hg hould be monitored cloely and may benefit from prophylactic treatment to lower intraocular preure.