Retinal change after macular tranlocation with 360-Degree retinotomy in monkey eye

Purpoe To determine the morphologic and functional change of the fovea and retina of monkey eye after macular tranlocation with 360-degree retinotomy. Deign Experimental tudy. Method The retina of eight monkey eye were urgically tranlocated with a 360-degree retinotomy with procedure imilar to thoe ued on human eye. At 1, 2, and 3 month after the urgery, the ix eye that had ucceful urgery were tudied by light and tranmiion electron microcopy, terminal deoxynucleotidyl tranferae (TdT)-dNTP terminal nick-end labeling (TUNEL) aay, and immunohitochemitry with peanut agglutinin (PNA) lectin and glial fibrillary acidic protein (GFAP). Retinal phyiology wa aeed by cotopic and photopic electroretinogram (ERG). Reult The fovea wa uccefully tranlocated approximately 30 to 40 degree uperiorly in ix eye. The tranlocated macula and fovea had a normal layered architecture with no TUNEL-poitive cell, minimal mialignment of the outer egment, and trong immunoreactivity to GFAP. The mean amplitude of the cotopic and photopic b-wave were ignificantly reduced at 1 month after the urgery, and there wa only a light recovery at 3 month. No ignificant change were oberved in the mean implicit time after the urgery. Concluion Thee finding indicate that macular tranlocation urgery with 360-degree retinotomy reult in minimal morphologic alteration but ignificant depreion of electrophyiologic function.