Human leukocyte antigen A29 ubtype aociated with birdhot retinochoroidopathy

Purpoe To determine whether birdhot retinochoroidopathy i aociated with ubtype of the human leukocyte antigen (HLA)-A29 other than HLA-A*2902. Deign Experimental tudy. Method High-reolution DNA typing of HLA-A29 ubtype wa performed on blood from 20 ubject with birdhot retinochoroidopathy uing polymerae chain reaction–baed typing method. Reult were compared with publihed control. Reult Four of 20 ubject (20%) had the HLA-A*2901 allele; two were homozygou for HLA-A*29, and both had the HLA-A*2901 and HLA-A*2902 allele. Among 18 ubject with only one HLA-A*29 allele, the HLA-A*2902 allele wa found in 16 (89%) and the HLA-A*2901 allele wa found in two (11%). No ubject wa found to have HLA-A*2903, HLA-A*2904, HLA-A*2905, or HLA-A*2906. Concluion Both HLA-A*2901 and HLA-A*2902 are aociated with birdhot retinochoroidopathy. Our data do not upport the previou uggetion that the HLA-A29.1 erotype may be protective againt development of birdhot retinochoroidopathy. Additional tudie will be required to determine whether the other, le common ubtype are aociated with the dieae. HLA-A29 ubtype teting i not required for the clinical evaluation of HLA-A29–poitive patient with birdhot retinochoroidopathy.