Effect of chronic ytemic ue of trimethoprim-ulfamethoxazole in the conjunctival bacterial flora of patient with HIV infection

Purpoe To invetigate the effect of orally adminitered trimethoprim-ulfamethoxazole (TMP-MZ) on the prevalence, pecie ditribution, and reitance of the conjunctival bacterial flora in adult with human immunodeficiency viru (HIV) infection. Deign Cro-ectional tudy, with clinical and experimental laboratory invetigation. Method ample from the inferior conjunctival fornix were collected and ubmitted for culture to evaluate aerobic flora. Reult ixty ample were collected. Negative culture were found in 17 (56.7%) eye of the TMP-MZ group and in 10 (33%) of the control group (P = .036). All taphylococcu pecie iolate in the TMP-MZ group were reitant to the drug, wherea 50% of the control group preented thi finding (P = .025). In the tudy group, all bacteria were reitant to TMP-MZ, compared with only 47% of the microorganim in the control group. Concluion Orally adminitered TMP-MZ in patient with HIV infection eem to exert a election preure in the microorganim preent on the conjunctiva.