A retropective tudy of endophtalmiti rate comparing quinolone antibiotic

Purpoe To compare endophthalmiti rate between topical quinolone antibiotic over a four-year period in a univerity etting. Deign Retropective, cro-ectional (prevalence) tudy. Method tudy population: Nine thouand eventy-nine patient who underwent a phacoemulification procedure at a Univerity Eye Center. INTERVENTION: The following intervention were conducted: ue of a noocomial infectiou reporting databae retropective analyi of propectively collected data to etablih endophthalmiti rate; prevalence analyi of potoperative quinolone antibiotic; analyi of endophthalmiti rate v potoperative quinolone precribed. main outcome meaure: Occurrence of endophthalmiti after cataract urgery. Reult During a four-year period involving 9079 phacoemulification procedure, 26 cae of bacterial potoperative endophthalmiti were reported (rate = 0.286%). Eight of the 26 cae were conidered complicated; 18 cae were uncomplicated. Among cae performed during thi period, potoperative precription volume for ciprofloxacin (Ciloxan, Alcon Laboratorie, Inc., Fortworth, Texa) and ofloxacin (Ocuflox, Allergan, Inc., Irvine, California) antibiotic drop were nearly identical, with 4538 patient receiving ciprofloxacin (49.98%) and 4541 patient receiving ofloxacin (50.02%). There were 22 endophthalmiti patient (85%) who had ued topical ciprofloxacin and 4 patient (15%) who had ued topical ofloxacin potoperatively. The difference in infectiou rate between antibiotic wa highly ignificant (P < .00026). For uncomplicated cae, 14 patient received ciprofloxacin and 4 patient received ofloxacin. Thi difference wa alo ignificant (P < .015). Concluion Difference in pharmacokinetic and pharmacodynamic propertie exit among quinolone antibiotic, which may affect endophthalmiti incidence following cataract urgery.