C677T variant in the methylentetrahydrofolate reductae gene i a genetic rik factor for primary open-angle glaucoma

Purpoe To etimate the prevalence of C677T ingle nucleotide polymorphim in the 5,10-methylentetrahydrofolate reductae (MTHFR) gene in primary open-angle glaucoma (POAG) and peudoexfoliation open-angle glaucoma (PEXG). Deign Cae-control tudy Method MTHFR wa aeed in 147 patient (76 POAG, 71 PEXG) and 71 control ubject with cataract. Aociation of genotype were aeed by Armitage’ trend tet and the correponding odd ratio (OR) for allele poitivity with 95% confidence interval (CI). Reult We oberved ignificant evidence of a higher prevalence of C677T in POAG (9% homozygote, 49% heterozygote, 42% wildtype, P = .01, OR = 2.38, 95% CI 1.23–4.62), but not in PEXG (9% homozygote, 41% heterozygote, 50% wildtype, P = .09, OR = 1.78, 95% CI 0.91–3.50) compared with the control (3% homozygote, 34% heterozygote, 63% wildtype). Concluion The MTHFR C677T variant leading to moderate hyperhomocyteinemia may play a role in the pathogenei of POAG acting a a genetic rik factor.