Quantitative Thickne Meaurement of Retinal Layer Imaged by Optical Coherence Tomography

Purpoe To report an image analyi algorithm that wa developed to provide quantitative thickne meaurement of retinal layer on optical coherence tomography (OCT) image. Deign Propective cro-ectional tudy. Method Imaging wa performed with an OCT3 commercial intrument in 10 viually normal healthy ubject. A dedicated oftware algorithm wa developed to proce the raw OCT image and detect the depth location of peak from intenity profile. Quantitative thickne meaurement of three retinal layer, in addition to total retinal thickne, were derived. Total retinal thickne meaurement obtained by the algorithm were compared with meaurement provided by the tandard OCT3 oftware. Reult The total retinal thickne profile demontrated foveal depreion, correponding to normal anatomy, with a thickne range of 160 to 291 μm. Retinal thickne meaured by the algorithm and by the tandard OCT3 oftware were highly correlated (R = 0.98). The inner retinal thickne profile predictably demontrated a minimum thickne at the fovea, ranging between 58 to 217 μm along the 6-mm can. The outer retinal thickne profile diplayed a maximum thickne at the fovea, ranging between 66 to 107 μm along the 6-mm can. The photoreceptor outer egment thickne profile wa relatively contant along the 6-mm can through the fovea, ranging between 42 to 50 μm. The intraubject variabilitie of the inner retina, outer retina, and photoreceptor outer egment thickne wa 14, 10, and 6 μm, repectively. Concluion Thickne meaurement of retinal layer derived from OCT image have potential value for objectively documenting dieae-related retinal thickne abnormalitie and monitoring progreive change over time.