Combined Eterified Etrogen and Methyltetoterone Treatment for Dry Eye yndrome in Potmenopaual Women

Purpoe To determine whether ytemic replacement with combined eterified etrogen (EE) and methyltetoterone (MT) (EE + MT) would reduce ymptom and promote clinical improvement in potmenopaual women with dry eye yndrome (DE). Deign Retropective, noncomparative, interventional cae erie. Method Invetigator reviewed the chart of 11 potmenopaual women treated within the lat 3 year with EE + MT. Reult The mean patient age wa 65.2 year (tandard deviation [D] 11.4, range 48–84 year). The mean treatment duration wa 12.2 month (D 6.2 month, range 4–24 month). Ten (91%) of 11 patient reported improvement in dry eye ymptom while receiving treatment. For thee 10, relief occurred after an average of 4.1 month of treatment (D 3.2, range, 1–9 month). Concluion Treatment with EE + MT may be efficaciou for DE of variou etiologie. A randomized placebo-controlled trial i planned to further evaluate thee encouraging finding.