Uing Optical Coherence Tomography to Monitor Photodynamic Therapy in Age Related Macular Degeneration

Purpoe To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovacularization (CNV) activity before and after photodynamic therapy (PDT) in patient with age-related macular degeneration (ARMD). Deign Propective obervational cae erie. Method etting: Intitutional tudy. patient population: Fifty-three patient (62 eye) with ARMD. obervation procedure: Propective obervational cae tudy. main outcome meaure: Preence or abence of leakage on fluorecein angiography, preence of intraretinal or ub-retinal fluid on OCT, and macular and choroidal neovacular complex thickne on OCT. Reult The macular thickne decreaed ignificantly after PDT (P = .001). However, no ignificant change in CNV thickne were meaured after PDT (P = .567). Once the diagnoi of ARMD wa etablihed before treatment, OCT had a enitivity of 96.77% for detecting CNV activity. After treatment, OCT had a good enitivity (95.65%) and a moderate pecificity (59.01%) in determining CNV activity, which reulted in a diagnotic efficiency (proportion of correct reult) of 82.95%. Concluion OCT appear to be ueful for indicating CNV activity. Therefore, it may erve a a complementary technique for deciding the need for PDT and re-treatment in patient with ARMD.