A Propective Randomized Clinical Trial of Laer In itu Keratomileui With Two Different Laer

Purpoe To compare optical quality, viual function, corneal hape, ocular wavefront aberration, and patient-reported ymptom and atifaction after laer in itu keratomileui (LAIK) with two different excimer laer. Deign Propective randomized clinical trial. Method In an intitutional practice etting, 60 eye of 30 patient with low to moderate myopia were randomized to receive LAIK in one eye with the Technola 217A; the other eye wa treated with the VIX 3. Patient were followed for 6 month after urgery. The primary outcome meaure wa bet pectacle-corrected viual acuity. Reult At 6 month, the mean bet-pectacle corrected high contrat viual acuity wa imilar between the two treatment group: mean difference (95% confidence interval) wa −0.01 logarithm of minimal angle of reolution (logMAR) (−0.03 to +0.01 logMAR). Uncorrected viual acuity difference were alo not ignificant. The difference in reidual pherical equivalent ubjective refractive error between treatment group wa −0.15 diopter (−0.34 to +0.05 diopter). pherical aberration increaed in both group after treatment, and the change in root mean quare (RM) ocular wavefront error wa greater in the VIX group by +0.07 μm (+0.03 to +0.11 μm). After LAIK, corneal curvature wa teeper in the midperipheral region among VIX-treated eye by +1.39 diopter (+2.06 to +0.72 diopter). There were no patient-reported difference in atifaction between eye. Concluion There were no ignificant difference in viual acuity or refractive outcome attributed to either laer under any of the condition meaured. There wa alo no ignificant difference in patient-reported ymptom, atifaction with treatment, or eye preference aociated with either laer. Additional tudy i needed to etablih the importance of difference in higher-order optical aberration and corneal hape that we oberved in thee two treatment group.