Vitrectomy for Peritent Diffue Diabetic Macular Edema

Purpoe To evaluate the potential benefit of vitrectomy in eye with peritent diffue macular edema. Deign Propective randomized comparative clinical trial. Method Eye with diffue diabetic macular edema for 6 to 18 month, an attached poterior hyaloid, and grid laer photocoagulation performed at leat 4 month before were included. Patient were randomized either to a vitrectomy group or to a control group. main outcome meaure: Evaluation of Early Treatment Diabetic Retinopathy tudy (ETDR) viual acuity, reading viion, and retinal thickne were carried out at baeline and 1, 3, and 6 month after enrollment. Reult Fifty-ix eye (100%) were enrolled in thi tudy. Twenty-five eye (44.6%) were randomized into Gr I (vitrectomy group) and 31 eye (55.4%) into Gr II (control). Both group were comparable in mean age (62.7 year and 63.9 year) and ditribution of gender (one third male, two third female). ETDR viual acuity howed a tatitical ignificance in favor of Gr I at all time point (P = .035 to .005 Fiher′ exact tet). With Jaeger chart a ignificance for Gr I wa found only at the 6-month examination (P = .01). With optical coherence tomography, the different behavior of retinal thickne change in both group during follow-up wa tatitically ignificant; P value were <.0001 for month 1, 3, and 6, preferring Gr I. Concluion We provide evidence that vitrectomy with internal limiting membrane peeling i uperior to obervation alone in eye with peritent diffue diabetic macular edema for 6 to 18 month. Longer follow-up period and larger erie might be needed to confirm thee reult and gain additional information.